Analysis of changes in cytokine concentrations and neutrophil activity in patients with essential arterial hypertension depending on the affected target organs against the background of antihypertensive therapy

Abstract

Introduction. It is known that the assessment of cytokine levels and neutrophil activity in the peripheral blood in patients with essential arterial hypertension will reveal differences depending on the target organ affected.

The aim of the study was to assess changes in cytokine concentrations and neutrophil activity in peripheral blood in patients with essential arterial hypertension and subclinical damage to target organs during antihypertensive therapy.

Material and methods. The study included 104 patients with grade II essential arterial hypertension, grade 2, aged 30 to 50 years with left ventricular myocardial hypertrophy (n = 33), with predominantly vascular lesions in the form of asymptomatic atherosclerosis (n = 35) and with predominant kidney damage in the form of the development of stage 3 chronic kidney disease (n = 36).

Results. The greatest changes in the concentration of cytokines (TNFα, IL-1α, IL-6, IL-8, IL-10, IL-1Ra, IL-2) in patients with essential arterial hypertension are determined in asymptomatic atherosclerosis. Disturbances of functional and metabolic activity (NBT-test spontaneous and stimulated) of peripheral blood neutrophils are more pronounced in patients with left ventricular myocardial hypertrophy. The immunocorrective efficacy of antihypertensive therapy in patients with essential arterial hypertension is more effective in patients with asymptomatic atherosclerosis and is least effective in patients with chronic kidney disease.

Conclusion. Determination of the concentration of cytokines and functional-metabolic activity of neutrophils in patients with essential arterial hypertension in patients with essential arterial hypertension will reveal differences depending on the affected target organ and thereby serve as a search for predictors of the development of irreversible changes in target organs with the development of associated clinical conditions and their complications.

Keywords:essential arterial hypertension; cytokines; neutrophils; target organs

For citation: Gavrilyuk E.V., Evsegneeva I.V., Mikhin V.P, Nurtazina A.Yu. Analysis of changes in cytokine concentrations and neutrophil activity in patients with essential arterial hypertension depending on the affected target organs against the background of antihypertensive therapy. Immunologiya. 2020; 41 (5): 441-7. DOI: https://doi.org/10.33029/0206-4952-2020-41-5-441-447 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

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