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3 . 2020

The role of cytokines in the pathogenesis of infective endocarditis


In recent years the interest in studying of the cytokines' immunopathogenetic role in the various infectious and inflammatory diseases formation has not weakened. Our review demonstrates the role of cytokines, produced after a direct contact with the antigen. Cytokines cannot be called as factors that relate only to the immune system. They connect the immune, nervous, endocrine, hematopoietic and other systems to engage in the regulation of a general protective reaction. Cytokines play an important role in hematopoietic, tissue homeostasis, intersystem signal transmission. With the development of inflammation, cytokines demonstrate a high spectrum of biological activity and provide maximum efficiency of those body systems that are required at the moment. Infective endocarditis (IE) is a disease of infectious nature with the primary localization of the pathogen on the heart valves and parietal endocardium. IE occurs with the possible generalization of the septic process and the development of immunopatho-logical manifestations. In this regard, the analyze of current information about the pathogenetic role of cytokines in infective endocarditis is the subject of interest in modern research. For the literature review used the databases: eLIBRARY, CyberLeninka, and Medline (Pubmed).

Keywords:infective endocarditis; bacterial endocarditis; diagnosis; pathogenesis; cytokines; review

For citation: Kolesnikova N.V, Samoylenko E.S. The role of cytokines in the pathogenesis of infective endocarditis. Immunologiya. 2020; 41 (3): 262-8. DOI: 10.33029/0206-4952-2020-41-3-262-268 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. Authors declare no conflict of interests.


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Rakhim M. Khaitov
Аcademician of the Russian Academy of Sciences, MD, Professor, Honoured Science Worker of the Russian Federation, Scientific Director of the NRC Institute of Immunology FMBA of Russia, Chief Allergist-Immunologist of the Ministry of Health of the Russian Federation

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