Efficiency of a dense extract of the sum of flavonoids in the form of ointment at treatment contact allergic dermatitis in experiment

Abstract

The aim of research is to study the specific activity of the preparation of external action of a dense extract of the sum of flavonoids from Bidens tripartitae.

Material and methods. The authors developed and studied a new medical product -a dense extract of the sum of flavonoids in the form of ointment obtained from Bidens tripartita, which was used for treatment of contact allergic dermatitis, experimentally induced in guinea pigs by 2,4-dinitrohlorbenzol.

Results of research have shown that 5 % ointment a medical product on the basis of a dense extract of the sum of flavonoids, visually operated on inflammatory process of integuments of porpoises in comparison of 1 % and 3 % with ointments on the basis of a dense extract of the sum of flavonoids, anthihistamine drug Psilo-Balsam® and glucocorticoid ointments Celestoderm B® century more effectively.

Conclusions. The studied 1, 3 and 5% ointments of dense extract of the sum of flavonoids have a pronounced effect on experimental contact dermatitis in guinea pigs. The greatest therapeutic effect has a 5 % ointment of a dense extract of the sum of flavonoids on a local basis for contact allergic dermatitis. At the same time the index of reducing the severity of skin manifestations (Ind) was the highest compared to other investigated groups - 37.9 %.

Keywords:1, 3 and 5 % ointment of a dense extract of the sum of flavonoids; experimental contact allergic dermatitis; 2,4-dinitrohlorbenzol

For citation: Khatamov H.M., Suyarov A.A., Kireev V.V., Ziyadullaev Sh.H., Muhtorov Sh.M., Alimzhanova L.I. Efficiency of a dense extract of the sum of flavonoids in the form of ointment at treatment contact allergic dermatitis in experiment. Immunologiya. 2020; 41 (3): 269-73. DOI: 10.33029/0206-4952-2020-41-3-269-273 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

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