Profi lling of HLA-B*27 allels in patients with ankylosing spondylitis

• Loginova M.A.
• Paramonov I.V.
• Guseva I.A.
• Dubinina Т.V.
• Podryadnova M.V.
• Erdes Sh.F.
• Fedorovskaya A.О.
• Nemtsov B.F.

Abstract

A study was made of the allelic profile of the HLA-B locus in 121 patients with ankylosing spondylitis. The HLA-B*27 gene was detected in all patients with ankylosing spondylitis, in 5 people - in the homozygote. Distribution of HLA-B*27 alleles - 27:05 (45.45%), 27:02 (6.20%), 27:04 (0.41%) - in patients with ankylosing spondylitis in the Russian population, similar to the distribution of these alleles among patients of the European cohort.

Keywords:ankylosing spondylitis; HLA-B*27 alleles; high resolution HLA-typing; Homozygosity; association

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