The HLA-Cw6 allele as the genetic predisposing factor to psoriasis in Tatar population

Abstract

Introduction. Psoriasis is an immune-mediated and multifactorial disease with a strong genetic background. HLA-Cw6 is one of the most strongly associated psoriasis susceptibility alleles.

Aim of the study was to assess the association allele HLA-Cw6 of HLA-C gene with psoriasis in Tatar patients with psoriasis in Volga-Ural region.

Material and methods. A case-control genetic association study was carried out. DNA samples obtained from a total of 106 cases and 175 healthy donors were examined. Genotyping allele HLA-Cw6 of the HLA-C gene was performed by PCR-RFLP (polymerase chain reaction-polymorphism of the lengths of restriction fragments).

Results. The presence of HLA-Cw6 allele was associated with psoriasis, being more frequent for patients with disease vs group of comparison (47 % и 16 %, respectively) (OR = 4.5; 95 % CI 2.85-7.15; p < 0.0005).

Conclusion. The present findings suggest that allele HLA-Cw6 of HLA-C gene contributes to the genetic susceptibility to psoriasis in the Tatar population.

Keywords:psoriasis; HLA-C; HLA-Cw6 allele; polymorphic variants; populations; association

For citation: Slesarenko Ya.S., Karnishkina O.Yu., Kilina D.A., Gumennaya E.R., Galimova E.S. The HLA-Cw6 allele as the genetic predisposing factor to psoriasis in Tatar population. Immunologiya. 2020; 41 (6): 511-8. DOI: https://doi.org/10.33029/0206-4952-2020-41-6-511-518 (in Russian)

Funding. The study was supported by the Russian Foundation for Basic Research grants 14-04-97026-r_ Volga region_a and 13-04-01489.

Conflict of interests. The authors declare no conflict of interests.

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