Epigenetics of bronchial asthma
AbstractBronchial asthma (BA) is a chronic inflammatory disease of the respiratory tract. The etiopathogenesis of BA is diverse and is still poorly understood. Epigenetic mechanisms of gene expression regulation are believed to be an important factor associated with the clinical heterogeneity of this disease. A number of studies have established the relationship of individual epigenetic features with predisposition to BA, with the severity of clinical manifestations of the disease, and with the nature of response to drug therapy. In particular, DNA methylation, regulation of genetic activity by microRNA molecules, and modifications of histones are considered to be important mechanisms of epigenetic regulation of inflammatory response of BA. In the review these mechanisms are examined in the context of BA pathogenesis and therapy and information on the main methods for assessing epigenetic modifications is provided. Further study of epigenetic aspects of BA is relevant and important not only from the point of view of basic science, but also of practical medicine, due to the possibility of personalization of BA diagnosis and therapy.
Keywords:epigenetics; pharmacoepigenetics; bronchial asthma; DNA methylation; microRNA; histones modifications
For citation: Timoshenko D.O., Kofiadi I.A., Gudima G.O., Kurbacheva O.M. Epigenetics of bronchial asthma. Immunologiya. 2021; 42 (2): 93-101. DOI: https://doi.org/10.33029/0206-4952-2021-42-2-93-101 (in Russian)
Funding. The study had no sponsor support.
Conflict of interests. The authors declare no conflict of interests.
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