Immunological aspects of the effects of mesotherapy with hyaluronic acid


Introduction. Despite numerous studies of the immunological aspects of mesotherapy with hyaluronic acid injections, not all of the effects have been studied.

The aim is to study the dynamics of the immunocompetent cells functioning during meso-correction with hyaluronic acid preparations, as well as to determine its effect on the function of the thyroid gland and psychoemotional state.

Material and methods. During dynamic observation of 26 patients before, just after, 3 and 6 months after the course of mesocorrection with hyaluronic acid preparations, the effects on the features of the clinical course, the dynamics of thyroid hormones and the emotional state. «Aramo Smart Lite 300» was used to objectify clinical changes. Quantitative and functional indicators of the innate and adaptive immune response were determined to characterize the immune system.

Results. Improvement in the parameters of skin moisture, the relief of skin creases was revealed, the tendency to decrease was determined only six months after the course of correction. The results of the analysis of immunological parameters indicate dynamic changes marked at the end of the course in the form of lymphocyte differentiation shift towards NK-cells and B-lymphocytes, increased production of IgM and IgG, decreased levels of IgA and IgE in serum, inhibition of oxygen-producing activity of neutrophils, changes of Toll-like receptors expression by monocytes. Further observation showed a return of all indicators to the initial level. The study of the quality of life of patients showed a significant improvement in the psychoemotional state immediately after the course and the persistence of improvements throughout the follow-up period.

Conclusion. The clinical effect is accompanied by changes in the parameters of the innate and adaptive immune response, recorded immediately after the completion of the procedure, which serves as an illustration of the involvement of immune processes in improving the moisture content, elasticity and relief of the skin.

Keywords:innate immunity, adaptive immunity; hyaluronic acid; mesotherapy

For citation: Sizyakina L.P, Sergeeva A.I. Immunological aspects of the effects of mesotherapy with hyaluronic acid. Immunologiya. 2021; 42 (2): 159-65. DOI: (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.


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Rakhim M. Khaitov
Аcademician of the Russian Academy of Sciences, MD, Professor, Honoured Science Worker of the Russian Federation, Scientific Director of the NRC Institute of Immunology FMBA of Russia, Chief Allergist-Immunologist of the Ministry of Health of the Russian Federation
Medicine today

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