The role of factors of innate immunity in the formation of adaptation to stress
AbstractIntroduction. Changes in the cellular factors of the innate immune system in the adaptation processes under stress have not been fully studied and the data on them are contradictory.
Aim of the study - research of the dynamic changes of cellular factors of innate immunity in military personnel under conditions of professional stress.
Material and methods. 37 servicemen (average age 37.3 ± 4.8 years) who participated in special operations (service in zones with an unfavorable operational situation lasting 3 months) were examined. The analysis of the cellular factors of the innate immune response was carried out before participating in special operations, immediately after returning from a zone with an unfavorable operational environment, and also after 3, 6, 12 months of observation.
Results. During dynamic observation of innate immunity parameters of military personnel participating in special operations, a weakening of the protective cytolitic activity of CD16+-cells was documented. A persistent inhibition of the processes of recognition and presentation of antigens at the level of TLR receptors of the monocytic link of the immune system was revealed.
Conclusion. Changes in the quantitative and functional parameters of cellular factors of innate immunity retained their significance in servicemen for a year after performing military duties in a zone with a difficult operational environment, which indicated the formation of persistent violations of the physiological adaptation process in the immune surveillance system.
Keywords:innate immunity; stress; adaptation
For citation: Zaitseva N.S., Sizyakina L.P The role of factors of innate immunity in the formation of adaptation to stress. Immunologiya. 2021; 42 (3): 270-6. DOI: https://doi.org/10.33029/0206-4952-2021-42-3-270-276 (in Russian)
Funding. The study had no sponsor support.
Conflict of interests. The authors declare no conflict of interests.
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