The proteins of γ-globulin fraction, that bind metal ions, in physiological immune regulation. Opposite effects of copper and zinc

• Sergey B. Cheknev

Abstract

The data summarized in the paper concerning possibility of metal ions chelation by proteins of human γ-globulin blood plasma fraction from their periglobular space and of conformational changes dealing with such a binding in normal physiological conditions that primarily cause the shifts in Fc-fragment structures. As a result of such shifts dynamics of interactions of γ-globulins with Fc-receptors (FcR) expressed on the surface of immune system cells does change, and intracell signaling caused by FcR activation as well as cell responses induced by signal transduction from FcR do also shift. Copper and zinc ions bound by γ-globulin fraction proteins and localized within antibodies molecules by specifically distributed by their topics binding sites cause opposite changes of effector properties of γ-globulins that reciprocally shift cell functions in response to FcR activation by the proteins transformed with metal binding. In physiological immune regulation the proteins of γ-globulin fraction chelating the single copper and zinc ions and exerting thereby opposite effector properties support induction of cellular immunity simultaneously excluding the tolerance burst and pathological reactions towards own normal human cells.

Keywords:γ-globulins; metal ions; chelation; opposite properties

References

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