The role of C-reactive protein, neopterin and melatonin in the diagnosis of Epstein-Barr virus infection

Abstract

Introduction. The complexity of the diagnosis of Epstein-Barr virus (EBV) infection determines the relevance of the search for non-specific markers indicating the activity of the process.

The aim of the study is to evaluate the role of C-reactive protein (CRP), neopterin and melatonin in the diagnosis of EBV infection.

Material and methods. The blood levels of CRP, neopterin, and melatonin were studied in 90 people with chronic EBV infection, including 45 people with reactivation (24 - in the early and 21 - in the late phase of reactivation) and 45 people with latent infection.

Results. The average concentration of CRP in individuals at the late phase of reactivation (193 mg/l) is significantly higher than in the group with latent EBV infection (60.5 mg/l). The frequency of exceeding the reference values of CRP in the studied groups did not significantly differ. Elevated levels of melatonin were significantly more often detected in individuals in the late phase compared to the subgroup in early reactivation, and lowered - on the contrary. The average concentration of melatonin in individuals in late reactivation (40.2 pg/ml) is significantly higher than in the early phase (18.9 pg/ml). Reduced values of neopterin among persons with virus reactivation were detected significantly less often than in the latent form. The average concentration of neopterin in individuals in a late reactivation phase (5.5 nmol/l) is significantly lower than in those in an early one (9.0 nmol/l).

Conclusion. The study of the levels of CRP, neopterin and melatonin allows us to determine the presence of an infectious process. Further research will allow us to outline new prospects for the diagnosis, therapy and prevention of EBV infection.

Keywords:Epstein-Barr virus; latent infection; reactivation; C-reactive protein; neopterin; melatonin

For citation: Solomay T.V., Semenenko T.A., Gotvyanskay T.P., Konopleva M.V., Davtyan S.A., Suslov A.P, Ilina N.I. The role of C-reactive protein, neopterin and melatonin in the diagnosis of Epstein-Barr virus infection. Immunologiya. 2021; 42 (5): 502-10. DOI: https://doi.org/10.33029/0206-4952-2021-42-5-502-510 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

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