The proteins of γ-globulin fraction binding metal ions, in physiological immune regulation. Mutual action of copper and zinc

• Sergey B. Cheknev

Abstract

The data are summarized in the paper concerning possibility of chelation by proteins of human y-globulin fraction of slow molar excess of metal ions from their periglobular space during tissue damages or inflammation. Copper and zinc ions bound by γ-globulin fraction proteins and localized within antibodies molecules by common groups of their binding sites cause similar changes of effector properties of γ-globulins that similarly shift cell functions in response to Fc receptor activation by the proteins transformed with metal binding. During tissue damages or inflammation the proteins of γ-globulin fraction chelating the slow molar excess of copper and zinc ions exert mutual effector properties, support induction of cellular immunity, and simultaneously exclude pathological reactions towards own normal human cells by enhancing production of functionally opposite cytokines.

Keywords:γ-globulins; metal ions; chelation; mutual action

References

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