Dermatologic adverse events of cancer immunotherapy with anti-PD-1 and anti-PD-L1 monoclonal antibodies

Abstract

The article describes major types of dermatologic immune-related adverse events during treatment with PD-1/PD-L1 immune checkpoint inhibitors. We present several clinical cases, describe current topical and systemic therapies of patients with such type of immune-mediated adverse events. In addition, the stepwise approach to the management ofpatients with dermatologic immune-related adverse events based on clinical course and severity grading is presented.

Keywords:immunotherapy; immune checkpoint inhibitors; PD-1/PD-L1; skin toxicity; immune-related adverse events; supportive care; oncodermatology

For citation: Shatokhina E.A., Polonskaia A.S., Kruglova L.S., Shatokhin M.N. Dermatologic adverse events of antitumor immunotherapy with anti-PD-1 and anti-PD-L1 monoclonal antibodies. Immunologiya. 2021; 42 (6): 641-54. DOI: https://doi.org/10.33029/0206-4952-2021-42-6-641-654 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

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