Immune response to Helicobacter pylori

• Vladimir Yu. Talayev
• Elena V. Voronina
• Irina Ye. Zaichenko
• Olga N. Babaykina

Abstract

H. pylori causes pathologies of different severity: asymptomatic infection, gastritis, gastric and duodenal ulcers, adenocarcinoma and MALT-lymphoma. According to available data, the form of the disease depends both on the virulence of the pathogen and on the characteristics of the immune response. It should be noted that in H. pylori infection the role of individual cell groups of the immune system is very ambiguous. Thus, pro-inflammatory T cell subgroups have a certain anti-infectious potential, but at the same time make a significant contribution to the development of inflammatory and destructive processes, while regulatory T cells weaken the clinical manifestations of infection, but contribute to the persistence of the pathogen. The review presents data on the role of various cells involved in the immune response to H. pylori, as well as information on the pathogenesis of lymphomas associated with H. pylori infection.

Keywords:Helicobacter pylori; immune response; inflammation; T-helper cells; regulatory T cells; cytokines; B cells; lymphoma

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