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2 . 2022

Immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome

Abstract

This review presents information about the role of the immune system in the development of multisystem inflammatory syndrome in children (MIS-C) associated with a new coronavirus infection (COVID-19). The main clinical criteria for establishing a diagnosis are presented, a description of the clinical picture and characteristics of biomarkers in MIS-C. Most researchers consider activation of the immune system with the development of a hyperergic inflammatory reaction to be the main cause of the development of a multisystem inflammatory syndrome. At the same time, the heterogeneity of MIS-C is the basis of various hypotheses of its development. The role of predisposing factors in the development of various variants of the immune response in MIS-C has yet to be established, research is ongoing.

Keywords:multisystem inflammatory syndrome in сhildren; MIS-C; immunopathogenesis; new coronavirus infection; COVID-19; children

For citation: Osmanov I.M., Khegai I.M., Trunina I.I., Chebotareva T.A., Cheburkin A.A., Shumilov P.V. Immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome. Immunologiya. 2022; 43 (1) 217–23. DOI: https://doi.org/10.33029/0206-4952-2022-43-1-217-223 (in Russian)

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

Authors contribution. Research concept and design, editing – Chebotareva T.A., Trunina I.I., Cheburkin A.A., Shumilov P.V., Osmanov I.M.; collection and processing of the material, writing of the text – Hegai I.M. Cheburkin A.A., Trunina I.I., Chebotareva T.A.

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