Preventive effectiveness of nasal interferon-gamma among adult volunteers against acute respiratory viral infections, including COVID-19 (in Russian)

Abstract

Background. In vitro studies showed effective viral infection block in case of pretreatment with exogenous interferons. Interferon-gamma is a unique immune interferon, actively expressed in patients with acute respiratory viral infections (ARVI) and defending the body from severe infection course.

Aim – to evaluate the safety and preventive effectiveness of nasal interferon-gamma protecting against ARVI, including COVID-19.

Material and methods. The study enrolled 630 adult volunteers with a negative PCR test result for SARS-CoV-2, without respiratory symptoms and contraindications to interferon-gamma. Participants were randomized (1 : 1) into 2 groups: the study group – with the use of a prophylactic course of nasal interferon-gamma, and the group of comparison – without a course of prophylaxis. All participants were given a diary for daily monitor respiratory symptoms, adverse events, and record the use of pharmacotherapy.

Results. Safety analysis found no differences between groups. During 28 days period a higher incidence of ARVI, including COVID-19, was observed in the group of comparison (13 vs 3 cases in the study group). The odd ratio was 0.224 (95 % CI: 0.040–0.826), p = 0.020. The total number of ARVI cases, including COVID-19, in the group of comparison during 2 months of research was 26 vs 6 in the study group. The odd ratio was 0.233 (95 % CI: 0.077–0.594), p = 0,001. The longest period of persistence of respiratory symptoms was obtained in the group of comparison (7 vs 4 days in the study group, р = 0.034).

Conclusion. Nasal interferon-gamma as a preventive measure contributes to a decrease of infection incidence of ARVI, including COVID-19.

Keywords:infection prevention; respiratory infection; interferon-gamma; healthy volunteers; ARVI; COVID-19

For citation: Talyzin P.A., Myasnikov A.L., Berns S.A., Ilyina M.A., Komazov A.A., Lynyov V.S., Ekusheva E.V. Preventive effectiveness of nasal interferon-gamma among adult volunteers against acute respiratory viral infections, including COVID-19. 2022; 43 (3): 288–300. DOI: https://doi.org/10.33029/0206-4952-2022-43-3-288-300 (in Russian)

Funding. The RAIN-2020 study was supported by the SPP «Pharmaclon» Ltd.

Conflict of interests. The authors declare no conflict of interests.

Authors’ contribution. Collection and processing of material – Ilyina M.A., Komazov A.A., Lynyov V.S.; writing text – Ilyina M.A., Komazov A.A., Berns S.A.; material editing – Talyzin P.A., Ilyina M.A., Lynyov V.S., Myasnikov A.L., Berns S.A., Komazov A.A.; approval of the final version of the article – Talyzin P.A., Myasnikov A.L., Lynyov V.S., Ekusheva E.V.; responsibility for the integrity of all parts of the article – Berns S.A., Myasnikov A.L., Talyzin P.A.

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EDITOR-IN-CHIEF
EDITOR-IN-CHIEF
Musa R. Khaitov

Corresponding member of Russian Academy of Sciences, MD, Professor, Director of the NRC Institute of Immunology FMBA of Russia

Вскрытие
Medicine today

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