The proteins of γ-globulin fraction, that bind metal ions, in physiological immune regulation. Polarization of the responses and rational limitation of inflammation

Abstract

The data are summarized in the paper allowing to describe effector properties of human γ-globulin fraction proteins that chelate copper and zinc ions, and due to their conformational changes translate the signals into the immune cells during activation of the cells and initiation of inflammation. It could be assumed that biochemical processes dealing with transport and exchange of metal ions in the cell environment, and involving the γ-globulin fraction proteins as translating macromolecules formed the basis for mechanism of rational limitation of inflammation and immunogenesis that in parallel with induction of cellular immunity seems to be evident to exclude pathological reactions towards own normal cells of the body by three levels of functional interactions.

Keywords:γ-globulins; metal ions; chelation; inflammation; limitation

For citation: Cheknev S.B. The proteins of γ-globulin fraction, that bind metal ions, in physiological immune regulation. Polarization of the responses and rational limitation of inflammation. Immunologiya. 2022; 43 (4): 468–76. DOI: https://doi.org/10.33029/0206-4952-2022-43-4-468-476 (in Russian)

Funding. The study was performed in the frame of State tasks of the Ministry of Health of the Russian Federation «Molecular and cellular basis for the antiinfectional immune resistance» dated April 4, 2012 (State registration N 01201255945) and «Mechanisms of regulation of natural and adaptive antiinfectional immunity» dated February 18, 2015 (State registration N 115030470028).

Conflict of interests. Author declares no conflict of interests.

Acknowledgment. The author thanks research scientist M.A. Sarycheva for the help in the manuscript preparation.

References

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