Allergen immunotherapy: on the path to achieving immune tolerance
AbstractAllergen immunotherapy (AIT) is one of the main methods for the pathogenetic treatment of IgE-mediated allergic diseases. The AIT degrades the sensitivity to a significant allergen and the clinical symptoms severity, reduces the risk of medications use, prevents the asthma and new sensitization. AIT-induced tolerance is an active highly-regulated state of immunity resistance to the allergen and is mediated by a complex interaction between various cells of the innate and adaptive immune system. Numerous cellular and molecular studies have brought us closer to understanding the processes that characterize allergic inflammation and AIT-induced immune tolerance. However, the AIT mechanism remains unclear. An understanding of the immune response modification during AIT is necessary for the physicians to predict the therapeutic effects and the timing of their achievement, assess the possibility of combining AIT with other methods of therapy, and minimize the risks of adverse events. This review describes modern conception of the IgE-mediated allergic reactions mechanisms and the AIT points of action.
Keywords:allergen-specific immunotherapy; allergen immunotherapy; AIT; mechanisms of allergen immunotherapy; immune tolerance
For citation: Pavlova K.S., Timoshenko D.O., Gushchin I.S., Kurbacheva O.M. Allergen immunotherapy: on the path to achieving immune tolerance. Immunologiya. 2024; 45 (1): 82–90. DOI: https://doi.org/10.33029/1816-2134-2024-45-1-82-90 (in Russian)
Funding. The study had no sponsor support.
Conflict of interests. The authors declare no conflict of interests.
Authors’ contribution. Search and analysis of literary sources, writing the text – Pavlova K.S., Timoshenko D.O., Gushchin I.S.; creation of the illustrative material for the article – Pavlova K.S., Timoshenko D.O., Kurbacheva O.M.; text editing and preparation an article – Kurbacheva O.M., Gushchin I.S.
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