Relapsing inflammatory diseases of the oropharynx - the role of mucosal immunity factors
AbstractFrequent relapses of inflammatory diseases of the upper respiratory tract (URT) - a condition that goes beyond purely otorhinolaryngological practice. Obviously, in such cases it is a violation of protective mechanisms at the system and/or local level. These patients are increasingly in the field of view of immunologists. Therefore, at the present stage it is necessary to understand both the etiopathogenetic state of this condition and the variants of the immunological dysfunction that forms in this group of patients.
The aim of this study was to determine the spectrum of the microbiological composition of the oropharynx and to investigate the factors of local immunity in patients with frequent recurrences of inflammatory diseases of the URT.
Material and methods. The bacterial microflora of the oropharynx was determined by sowing from throat, tonsils, the presence and concentration of herpes-group viruses in whole saliva (real-time PCR method). The concentration of protective factors of saliva (α-defensins, catelicidin LL-37, lactoferrin, secretory IgA) was also determined in patients with frequent recurrences of inflammatory diseases of the URT outside the exacerbation period.
Results. In a person who is often ill adults, the microbial landscape outside the period of exacerbation is represented by a combined bacterial (less pathogenic, mostly conditionally pathogenic) and viral (mainly EBV, HHV 6) microflora. Also in these patients there is a disturbance in the production of mucosal immunity factors.
Keywords:EBV; HHV 6; antimicrobial peptides; defensins; catalethicin LL-37; lactoferrin; secretory IgA
Received 18.09.2018. Accepted 16.11.2018.
For citation: Shchubelko R.V., Zuikova I.N., Shuljenko A.E., Andreev I.V., Avoyan G.E., Surova O.S. Relapsing inflammatory diseases of the oropharynx - the role of mucosal immunity factors. Immunologiya. 2019; 40 (1): 35-42. doi: 10.24411/0206-4952-2019-11004. (in Russian)
Acknowledgments. The study had no sponsorship.
Conflict of interest. The authors declare no conflict of interest.
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