Regulatory B cells: role in the immune response to tumor

Abstract

B cells are key mediators of humoral immunity and the second most important population of adaptive immune cells after T cells, playing a significant role in various conditions, including infections, allergies, autoimmune diseases, transplantation, and malignant tumors. B cells are considered as key players in modulating the immune response in cancer. Various B cell populations have been found in the tumor microenvironment, ranging from naive B cells to terminally differentiated plasma cells and memory B cells. They are capable of exhibiting both antitumor and protumor activity and can play an important role in immunotherapy of cancer. This article is a review of foreign and domestic literature devoted mainly to regulatory B cells and their role in the immune response to tumors. The review of literature devoted mainly to regulatory B cells and their role in the immune response to tumors.

Keywords: B cells; regulatory B cells; effector B cells; malignancies

For citation: Kadagidze Z.G., Chertkova A.I., Borunova A.A., Zabotina T.N. Regulatory B cells: role in the immune response to tumor. Immunologiya. 2025; 46 (1): 62–72. DOI: https://doi.org/10.33029/1816-2134-2025-46-1-62-72 (in Russian)

Funding. The work had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

Authorsʼ contribution. Literature analysis, article writing – Zabotina T.N., Borunova A.A.; literature search and analysis, article writing – Chertkova A.I.; editing, approval of the final text of the article – Kadagidze Z.G.

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