References
1. Laumont C.M., Banville A.C., Gilardi M., Hollern D.P., Nelson B.H. Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities. Nat Rev Cancer. 2022; 22 (7): 414–30. DOI: https://doi.org/10.1038/s41568-022-00466-1
2. Wei Y., Huang C.X., Xiao X., Chen D.P., Shan H., He H., Kuang D.M. B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments. Oncogene. 2021; 40 (29): 4737–45. DOI: https://doi.org/10.1038/s41388-021-01918-y
3. Wang L., Fu Y., Chu Y. Regulatory B cells. Adv Exp Med Biol. 2020; 1254: 87–103. DOI: https://doi.org/10.1007/978-981-15-3532-1_8
4. Chen J., Tan Y., Sun F., Hou L., Zhang C., Ge T., Yu H., Wu C., Zhu Y., Duan L., Wu L., Song N., Zhang L., Zhang W., Wang D., Chen C., Wu C., Jiang G., Zhang P. Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer. Genome Biol. 2020; 21 (1): 152. DOI: https://doi.org/10.1186/s13059-020-02064-6
5. Li M., Quintana A., Alberts E., Hung M.S., Boulat V., Ripoll M.M., Grigoriadis A. B cells in breast cancer pathology. Cancers (Basel). 2023; 15 (5): 1517. DOI: https://doi.org/10.3390/cancers15051517
6. Veh J., Ludwig C., Schrezenmeier H., Jahrsdörfer B. Regulatory Bcells-immunopathological and prognostic potential in humans. Cells. 2024; 13 (4): 357. DOI: https://doi.org/10.3390/cells13040357
7. Flores-Borja F., Blair P. Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses. Clin Exp Immunol. 2022; 209 (1): 33–45. DOI: https://doi.org/10.1093/cei/uxac029
8. Sanz I., Wei C., Jenks S.A., Cashman K.S., Tipton C., Woodruff M.C., Hom J., Lee F.E. Challenges and opportunities for consistent classification of huma B cell and plasma cell populations. Front Immunol. 2019; 10: 2458. DOI: https://doi.org/10.3389/fimmu.2019.02458
9. Lushova A.A., Zheremyan E.A., Astakhova E.A., Spiridonova A.B., Byazrova M.G., Filatov A.V. B-lymphocyte subsets: functions and molecular markers. Immunologiya. 2019; 40 (6): 63–76. DOI: https://doi.org/10.24411/02064952-2019-16009 (in Russian)
10. Ahsan N.F., Lourenço S., Psyllou D., Long A., Shankar S., Bashford-Rogers R. The current understanding of the phenotypic and functional properties of human regulatory B cells (Bregs). Oxf Open Immunol. 2024; 5 (1): iqae012. DOI: https://doi.org/10.1093/oxfimm/iqae012
11. Jansen K., Cevhertas L., Ma S., Satitsuksanoa P., Akdis M., van de Veen W. Regulatory B cells, A to Z. Allergy. 2021; 76 (9): 2699–715. DOI: https://doi.org/10.1111/all.14763
12. Matsumoto M., Baba A., Yokota T., Nishikawa H., Ohkawa Y., Kayama H., Kallies A., Nutt S.L., Sakaguchi S., Takeda K., Kurosaki T., Baba Y. Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation. Immunity. 2014; 41 (6): 1040–51. DOI: https://doi.org/10.1016/j.immuni.2014.10.016
13. Shankar S., Stolp J., Juvet S.C., Beckett J., Macklin P.S., Issa F., Hester J., Wood K.J. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022; 13 (1): 3121. DOI: https://doi.org/10.1038/s41467-022-30613-z
14. Baba Y., Matsumoto M., Kurosaki T. Signals controlling the development and activity of regulatory B-lineage cells. Int Immunol. 2015; 27 (10): 487–93. DOI: https://doi.org/10.1093/intimm/dxv027
15. Wang K., Liu J., Li J. IL-35-producing B cells in gastric cancer patients. Medicine (Baltimore). 2018; 97 (19): e0710. DOI: https://doi.org/10.1097/MD.0000000000010710
16. Bod L., Kye Y.C., Shi J., Torlai Triglia E., Schnell A., Fessler J., Ostrowski S.M., Von-Franque M.Y., Kuchroo J.R., Barilla R.M., Zaghouani S., Christian E., Delorey T.M., Mohib K., Xiao S., Slingerland N., Giuliano C.J., Ashenberg O., Li Z., Rothstein D.M., Fisher D.E., Rozenblatt-Rosen O., Sharpe A.H., Quintana F.J., Apetoh L., Regev A., Kuchroo V.K. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023; 619 (7969): 348–56. DOI: https://doi.org/10.1038/s41586-023-06231-0
17. Guan H., Lan Y., Wan Y., Wang Q., Wang C., Xu L., Chen Y., Liu W., Zhang X., Li Y., Gu Y., Wang Z., Xie F. PD-L1 mediated the differentiation of tumor-infiltrating CD19(+) B lymphocytes and T cells in invasive breast cancer. Oncoimmunology. 2016; 5: e1075112. DOI: https://doi.org/10.1080/2162402X.2015.1075112
18. Choi J.K., Egwuagu C.E. Interleukin 35 Regulatory B Cells. J Mol Biol. 2021; 433 (1): 166607. DOI: https://doi.org/10.1016/j.jmb.2020.07.019
19. Tedder T.F. B10 cells: a functionally defined regulatory B cell subset. J Immunol. 2015; 194 (4): 1395–401. DOI: https://doi.org/10.4049/jimmunol.1401329
20. Mohib K., Rothstein D.M., Ding Q. Characterization and activity of TIM-1 and IL-10-reporter expressing regulatory B cells. Methods Mol Biol. 2021; 2270: 179–202. DOI: https://doi.org/10.1007/978-1-0716-1237-8_10
21. Xia C., Yin S., To K.K.W., Fu L. CD39/CD73/A2AR pathway and cancer immunotherapy. Mol Cancer. 2023; 22 (1): 44. DOI: https://doi.org/10.1186/s12943-023-01733-x
22. Sun C., Wang B., Hao S. Adenosine-A2A receptor pathway in cancer immunotherapy. Front Immunol. 2022; 13: 837230. DOI: https://doi.org/10.3389/fimmu.2022.837230.eCollection2022
23. Figueiró F., Muller L., Funk S., Jackson E.K., Battastini A.M., Whiteside T.L. Phenotypic and functional characteristics of CD39high human regulatory B cells (Breg). Oncoimmunology. 2016; 5 (2): e1082703. DOI: https://doi.org/10.1080/2162402X.2015.1082703
24. Kozlov V.A., Demina D.V. Tryptophan and indoleamine2,3-dioxygenase (IDO) in pathogenesis of immunosuppressive clinical conditions. Medical Immunology. 2017; 19 (3): 225–40. DOI: https://doi.org/10.15789/1563-0625-2017-3-225-240 (in Russian)
25. Nouël A., Pochard P., Simon Q., Ségalen I., Le Meur Y., Pers J.O., Hillion S.J. B-Cells induce regulatory T cells through TGF-β/IDO production in A CTLA-4 dependent manner. Autoimmun. 2015; 59: 53–60. DOI: https://doi.org/10.1016/j.jaut.2015.02.004
26. Downs-Canner S.M., Meier J., Vincent B.G., Serody J.S. B cell functions in the tumor microenvironment. Annu Rev Immunol. 2022; 40: 169–93. DOI: https://doi.org/10.1146/annurev-immunol-101220-015603
27. Horii M., Matsushita T. Regulatory B cells and T cell regulation in cancer. J Mol Biol. 2021; 433 (1): 166685. DOI: https://doi.org/10.1016/j.jmb.2020.10.019
28. Qiu Z., Li Q., Lu Y., Wang Q. Clinical significance and prognostic value of circulating B10 cells in colorectal cancer. Asia Pac J Clin Oncol. 2022; 18 (2): e157–e162. DOI: https://doi.org/10.1111/ajco.13586
29. Jung Y.J., Woo J.S., Hwang S.H., Yang S., Kim S.J., Jhun J., Lee S.Y., Lee K.H., Cho M.L., Song K.Y. Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer. Cell Commun Signal. 2023; 21 (1): 320. DOI: https://doi.org/10.1186/s12964-023-01174-5
30. Lindner S., Dahlke K., Sontheimer K., Hagn M., Kaltenmeier C., Barth T.F., Beyer T., Reister F., Fabricius D., Lotfi R., Lunov O., Nienhaus G.U., Simmet T., Kreienberg R., Möller P., Schrezenmeier H., Jahrsdörfer B. Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells. Cancer Res. 2013; 73 (8): 2468–79. DOI: https://doi.org/10.1158/0008-5472.CAN-12-3450
31. Chesneau M., Le Mai H., Brouard S. New method for the expansion of highly purified human regulatory granzyme B-expressing B cells. Methods Mol Biol. 2021; 2270: 203–16. DOI: https://doi.org/10.1007/978-1-0716-1237-8_11
32. Sailliet N., Mai H.L., Dupuy A., Tilly G., Fourgeux C., Braud M., Giral M., Robert J.M., Degauque N., Danger R., Poschmann J., Brouard S. Human granzyme B regulatory B cells prevent effector CD4+CD25– T cell proliferation through a mechanism dependent from lymphotoxin alpha. Front Immunol. 2023; 14: 1183714. DOI: https://doi.org/10.3389/fimmu.2023.1183714
33. Zhu H., Xu J., Wang W., Zhang B., Liu J., Liang C., Hua J., Meng Q., Yu X., Shi S. Intratumoral CD38+CD19+B cells associate with poor clinical outcomes and immunosuppression in patients with pancreatic ductal adenocarcinoma. EBioMedicine. 2024; 103: 105098. DOI: https://doi.org/10.1016/j.ebiom.2024.105098
34. Huai G., Markmann J.F., Deng S., Rickert C.G. TGF-β-secreting regulatory B cells: unsung players in immune regulation. Clin Transl Immunology. 2021; 10 (4): e1270. DOI: https://doi.org/10.1002/cti2.1270
35. Harris R.J., Willsmore Z., Laddach R., Crescioli S., Chauhan J., Cheung A., Black A., Geh J.L.C., Mac Kenzie Ross A.D., Healy C., Tsoka S., Spicer J., Lacy K.E., Karagiannis S.N. Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs. Oncoimmunology. 2022; 11(1): 2104426. DOI: https://doi.org/10.1080/2162402X.2022.2104426
36. Wang W.W., Yuan X.L., Chen H., Xie G.H., Ma Y.H. Zheng Y.X., Zhou Y.L., Shen L.S. CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer. Oncotarget. 2015; 6 (32): 33486–99. DOI: https://doi.org/10.18632/oncotarget.5588
37. Yang C., Zhang Y., Wang R., Cheng B., Wu Y., Fu X. IL-10(+)CD19(+) regulatory B cells induce CD4(+)Foxp3(+)regulatory T cells in serum of cervical cancer patients. Autoimmunity. 2024; 57 (1): 2290909. DOI: https://doi.org/10.1080/08916934.2023.2290909
38. Huang H., Yao Y., Shen L., Jiang J., Zhang T., Xiong J., Li J., Sun S., Zheng S., Jia F., Zhou J., Yu X., Chen W., Shen J., Xia W., Shao X., Wang Q., Huang J., Ni C. CD24hiCD27+ Bregs within metastatic lymph nodes promote multidrug resistance in breast cancer. Clin Cancer Res. 2023; 29 (24): 5227–43. DOI: https://doi.org/10.1158/1078-0432.CCR-23-1759
39. Kadagidze Z.G., Chertkova A.I., Zabotina T.N., Gordeeva O.O., Borunova A.A., Shoua E.K., Zakharova E.N., Tabakov D.V. The relationship of markers of early and late lymphocytes activation with the effectiveness of neoadjuvant chemotherapy in patients with triple negative breast cancer with the efficiency of neoadjuvant chemotherapy in triple negative breast cancer patients. Immunologiya. 2021; 42 (2): 112–24. DOI: https://doi.org/10.33029/0206-4952-2021-42-2-112-124 (in Russian)
40. Imahashi N., Basar R., Huang Y., Wang F., Baran N., Banerjee P.P., Lu J., Nunez Cortes A.K., Uprety N., Ensley E., Muniz-Feliciano L., Laskowski T.J., Moyes J.S., Daher M., Mendt M., Kerbauy L.N., Shanley M., Li L., Lim F.L.W.I., Shaim H., Li Y., Konopleva M., Green M., Wargo J., Shpall E.J., Chen K., Rezvani K.J. Activated B cells suppress T-сell function through metabolic competition. Immunother Cancer. 2022; 10 (12): e005644. DOI: https://doi.org/10.1136/jitc-2022-005644
41. Li Q., Lao X., Pan Q., Ning N., Yet J., Xu Y., Li S., Chang A.E. Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression. Clin Cancer Res. 2011; 17: 4987–95. DOI: https://doi.org/10.1158/10780432.ccr-11-0207
42. Wouters M.C.A., Nelson B.H. Prognostic significance of tumor-infiltrating B cells and plasma cells in human cancer. Clin Cancer Res. 2018; 24 (24): 6125–35. DOI: https://doi.org/10.1158/1078-0432.CCR-18-1481
43. Nelson B.H. CD20+ B cells: the other tumor-infiltrating lymphocytes. J Immunol. 2010; 185 (9): 4977–82. DOI: https://doi.org/10.4049/jimmunol.1001323
44. Rivera A., Chen C.C., Ron N., Dougherty J.P., Ron Y. Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol. 2001; 13 (12): 1583–93. DOI: https://doi.org/10.1093/intimm/13.12.1583
45. Gilbert A.E., Karagiannis P., Dodev T., Koers A., Lacy K., Josephs D.H., Takhar P., Geh J.L., Healy C., Harries M., Acland K.M., Rudman S.M., Beavil R.L., Blower P.J., Beavil A.J., Gould H.J., Spicer J., Nestle F.O., Karagiannis S.N. Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies. PLoS One. 2011; 6 (4): e19330. DOI: https://doi.org/10.1371/journal.pone.0019330
46. Bao J., Betzler A.C., Hess J., Brunner C. Exploring the dual role of B cells in solid tumors: implications for head and neck squamous cell carcinoma. Front Immunol. 2023; 14: 1233085. DOI: https://doi.org/10.3389/fimmu.2023.1233085
47. Biswas S., Mandal G., Payne K.K., Anadon C.M., Gatenbee C.D., Chaurio R.A., Costich T.L., Moran C., Harro C.M., Rigolizzo K.E., Mine J.A., Trillo-Tinoco J., Sasamoto N., Terry K.L., Marchion D., Buras A., Wenham R.M., Yu X., Townsend M.K., Tworoger S.S., Rodriguez P.C., Anderson A.R., Conejo-Garcia J.R. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. 2021; 591 (7850): 464–70. DOI: https://doi.org/10.1038/s41586-020-03144-0
48. Esparcia-Pinedo L., Romero-Laorden N., Alfranca A. Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer. Front Immunol. 2023; 14: 1231315. DOI: https://doi.org/10.3389/fimmu.2023.1231315
49. Yuen G.J., Demissie E., Pillai S. B lymphocytes and cancer: a love-hate relationship. Trends Cancer. 2016; 2 (12): 747–57. DOI: https://doi.org/10.1016/j.trecan.2016.10.010
50. Sautès-Fridman C., Petitprez F., Calderaro J., Fridman W.H. Tertiary lymphoid structures in the era of cancer immunotherapy. Nat Rev Cancer. 2019; 19 (6): 307–25. DOI: https://doi.org/10.1038/s41568-019-0144-6
51. Meylan M., Petitprez F., Becht E., Bougoüin A., Pupier G., Calvez A., Giglioli I., Verkarre V., Lacroix G., Verneau J., Sun C.M., Laurent-Puig P., Vano Y.A., Elaïdi R., Méjean A., Sanchez-Salas R., Barret E., Cathelineau X., Oudard S., Reynaud CA., de Reyniès A., Sautès-Fridman C., Fridman W.H. Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer. Immunity. 2022; 55 (3): 527–41.e5. DOI: https://doi.org/10.1016/j.immuni.2022.02.001
52. Cabrita R., Lauss M., Sanna A., Donia M., Skaarup Larsen M., Mitra S., Johansson I., Phung B., Harbst K., Vallon-Christersson J., van Schoiack A., Lövgren K., Warren S., Jirström K., Olsson H., Pietras K., Ingvar C., Isaksson K., Schadendorf D., Schmidt H., Bastholt L., Carneiro A., Wargo J.A., Svane I.M., Jönsson G. Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature. 2020; 577 (7791): 561–5. DOI: https://doi.org/10.1038/s41586-019-1914
53. Bogdanova I.M., Artemyeva K.A., Boltovskaya M.N. Development and function of regulatory B cells and its role in pregnancy support. Immunologiya. 2021; 42 (4): 415–25. DOI: https://doi.org/10.33029/0206-49522021-42-4-415-425 (in Russian)