Peculiarities of cytokine regulation in schoolchildren with gastritis

• Vshivkov V.A.
• Polivanova T.V.
• Kasparov E.V.
• Peretyatko O.V.

Abstract

Abstract. The cytokine regulation of the inflammatory process in the gastric mucosa is caused ethnic characteristics of schoolchildren of the Republic of Tuva (a region with a high incidence of gastric cancer in the adult population).

The aim is study the association of cytokine levels at serum with clinical and morphological manifestations in gastritis by schoolchildren of aboriginal and foreign population of the Republic of Tuva in age groups.

Material and methods. We examined 89 schoolchildren of Tuva at the age of 7-17 years (32 aboriginal and 57 foreign). A gastroscopy was made with biopsy sampling for morphological confirmation of the diagnosis of gastritis. Diagnostics of gastritis was performed in accordance with the modified Sydney classification. Age groups was analyzed the 7-11 and 12-17 years.

Results. IL-10 in serum elevated In Tuvans with gastritis in the presence of dyspeptic manifestations at compare with Tuvans without complaints (p = 0.0253) and Europeoids with dyspepsia (p = 0.0157). Association of cytokine level with dyspepsia is not, but is with the activity of gastritis at age groups of schoolchildren of both populations. We were increase in proinflammatory IL-8 activity in antrum (p = 0.0485) and in the body of the stomach (p = 0.0485) of gastritis II-III degrees at Europeoids of 7-11 years. The level of anti-inflammatory IL-4 (p = 0.0189) was increased in young Tuvans with high gastritis activity in the body of stomach. IL-1β was decreased In Tuvans with age at gastritis with high activity in both parts of the stomach.

Discussion. The obtain data indicate about presence ethnic features of the immune response in the formation and course of gastritis. This is evidenced the dynamics of association indicators of cytokines IL-4, IL-8, IL-1β, regulating various parts of the immune system, with clinical and morphological manifestations at gastritis by schoolchildren of Tuva.

Conclusion. The features of association of cytokines IL-4, IL-8, IL-1β were installed with clinical and morphological manifestations in gastritis by children of aboriginal and foreign population of the Republic of Tuva, including depending of age.

Keywords:cytokines; gastritis; schoolchildren of Tyva

References

1. Vorobiyova A.V. The peculiarities of chronic gastroduodenitis in children (literature review). Vestnik novykh meditsinskikh tekhnologii (Elektronnoe izdanie). 2016; 10 (1): 229-34. (in Russian)

2. Malanicheva T.G., Ziatdinova N.V., Denisova S.N. Prevalence of upper gastrointestinal tract diseases in infants and preschool children. Eksperimental’naya i klinicheskaya gastoenterologiya. 2012; 1: 55-8. (in Russian)

3. Shcherbakov P.L. Modern problems of teenage gastroenterology. Pediatriya. 2010; 89 (2): 6-11. (in Russian)

4. Tokuda Y., Takahashi O., Ohde S., Shakudo M., et al. Gastrointestinal symptoms in a Japanese population: a health diary study. World J. Gastroenterol. 2007; 13 (4): 572-8.

5. Qu X., Tang Y., Hua S. Immunological approaches towards cancer and inflammation: a cross talk. Front. Immunol. 2018; 9: 563.

6. Vshivkov V.A., Polivanova T.V., Kasparov E.V., Peretyat’ko O.V., et al. State of the mucous membrane of the gastroduodenal zone in schoolchildren of the region with a high prevalence of gastric cancer. Rossiyskiy pediatricheskiy zhurnal. 2018; 21 (1): 26-30. (in Russian)

7. Aksel’ E.M. Statistics of malignant tumors of the gastrointestinal tract. Sibirskiy onkologicheskiy zhurnal. 2017; 16 (3): 5-11. (in Russian)

8. Zhu C., Ren C., Han J., Ding Y., et al. A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. Br. J. Cancer. 2014; 110 (9): 2291-9.

9. Ueda J., Gosho M., Inui Y., Matsuda T., et al. Prevalence of Helicobacter pylori infection by birth year and geographic area in Japan. Helicobacter. 2014; 19 (2): 105-10.

10. Drossman D.A. Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology. 2016; 150: 1262-79.

11. Aruin L.I., Kononov A.V., Mozgovoi S.I. International classification of chronic gastritis: what should be taken and what is in doubt. Arkhiv patologii. 2009; 71 (4): 11-7. (in Russian)

12. Dixon M.F., Genta R.M., Yardley J.H. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis. Helicobacter. 1997; 2 (1): 17-24.

13. Sha W., Pasricha P.J., Chen J.D. Correlations among electrogastrogram, gastric dysmotility, and duodenal dysmotility in patients with functional dyspepsia. J. Clin. Gastroenterol. 2009; 43 (8): 716-22.

14. Tack J., Talley N.J. Gastroduodenal вisorders. Am. J. Gastroenterol. 2010; 105 (4): 757-63.

15. Geginat J., Larghi P., Paroni M., Nizzoli G., et al. The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer. Cytokine Growth Factor Rev. 2016; 30: 87-93.

16. Valenzuela M.A., Canales J., Corvalán A.H., Quest A.F. Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J. Gastroenterol. 2015; 21 (45): 12 742-56.

17. Noto J.M., Peek R.M. The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer. PLoS Pathog. 2017; 13 (10): e1006573

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629027/

doi: 10.1371/journal.ppat.1006573

18. Siregar G.A., Halim S., Sitepu V.R. Serum TNF-a, IL-8, VEGF levels in Helicobacter pylori infection and their association with degree of gastritis. Acta Med. Indones. 2015; 47 (2): 120-6.

19. Krupa A., Fol M., Dziadek B.R., Kepka E., et al. Binding of CXCL8/IL-8 to Mycobacterium tuberculosis modulates the innate immune response. Mediators Inflamm. 2015; 2015: 124762

URL: https://www.ncbi.nlm.nih.gov/pubmed/26300588

doi: 10.1155/2015/124762

20. Dong C., Fu T., Ji J., Li Z., et al. The role of interleukin-4 in rheumatic diseases. Clin. Exp. Pharmacol. Physiol. 2018; 45 (8): 747-54.

21. Bent R., Moll L., Grabbe S., Bros M. Interleukin-1 beta-A friend or foe in malignancies? Int. J. Mol. Sci. 2018; 19 (8): E2155. doi: 10.3390/ijms19082155.

URL: https://www.ncbi.nlm.nih.gov/pubmed/30042333

doi: 10.3390/ijms19082155

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)